Publications by authors named "N A Sampson"
Background: Heterogeneity of treatment effects (HTEs) can occur because of either differential treatment compliance or differential treatment effectiveness. This distinction is important, as it has action implications, but it is unclear how to distinguish these two possibilities statistically in precision treatment analysis given that compliance is not observed until after randomization. We review available statistical methods and illustrate a recommended method in secondary analysis in a trial focused on HTE.
View Article and Find Full Text PDFDimethyladenosine transferase 1 (DIMT1) is an RNA -dimethyladenosine (mA) methyltransferase. DIMT1's role in pre-rRNA processing and ribosome biogenesis is critical for cell proliferation. Here, we investigated the minimal number of residues in a positively charged cleft on DIMT1 required for cell proliferation.
View Article and Find Full Text PDF(), the causative agent of tuberculosis, is a major global health concern. TetR family repressors (TFRs) are important for 's adaptation to the human host environment. Our study focuses on one notable repressor, Mce3R, composed of an unusual double TFR motif.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to create a composite score to measure how well US Army combat arms soldiers can handle combat-related stressors (CRS) before deployment and how this relates to persistent PTSD symptoms afterwards.!* -
- Researchers collected pre-deployment survey data from 2,542 soldiers and assessed PTSD levels two to nine months after returning from deployment, finding that 5.4% developed persistent PTSD, mostly among those with high levels of CRS.!* -
- The findings indicate that a reliable pre-deployment resilience score can predict how soldiers might be affected by high CRS, suggesting that such a score could help target preventative measures against PTSD.!*
Article Synopsis
- A large-scale, cross-national study examined the impact of removing the "excessiveness" requirement for diagnosing generalized anxiety disorder (GAD) among individuals living in challenging circumstances.
- Data from over 133,000 adults across various income countries revealed that eliminating this criterion raises the global prevalence of GAD from 2.6% to 4.0%, especially in low- and middle-income countries.
- Non-excessive worriers, while less severe, exhibit similar socio-demographic traits and impairment levels as excessive worriers, indicating they are significant cases deserving diagnosis and treatment.