Publications by authors named "N A Ryzhikova"
Article Synopsis
- T-cell leukemia from large granular lymphocytes (T-LGL leukemia) is a rare type of cancer, with γδT-LGL leukemia making up about 17% of cases and being linked to autoimmune diseases like rheumatoid arthritis (RA).
- A study analyzed 15 patients with γδT-LGL leukemia and rheumatologic diseases, finding that most had RA, with notable symptoms such as splenomegaly and neutropenia.
- The research highlighted that mutations were common, particularly in certain genes, and showed unusual characteristics of γδT-LGL leukemia, mainly affecting the spleen and not appearing in peripheral blood, prompting the need for further investigation into the relationship between this leukemia and RA.
Article Synopsis
- - Neutropenia is common in Felty syndrome (FS) and T-cell large granular lymphocytic (T-LGL) leukemia associated with rheumatoid arthritis (RA), with TCR gene rearrangements supporting a diagnosis of T-LGL leukemia but not FS.
- - A study analyzed 100 RA patients with unexplained neutropenia, finding STAT3 mutations in 71% of those with RA-associated T-LGL leukemia versus only 10% in FS, indicating a significant difference (p=4.7×10-8).
- - The findings suggest that STAT3 mutations are rare in FS but common in T-LGL leukemia; detecting these mutations can help diagnose T-LGL leukemia even without TCR rearrangement
The relationship between Sjögren syndrome (SS) and T-cell large granular lymphocytic (T-LGL) leukemia remains unclear. In this paper, we report for the first time a large case series of 21 patients with primary and secondary SS associated with T-LGL leukemia. Our results suggest the importance of considering T-LGL leukemia in the diagnostic evaluation of SS patients, particularly when neutropenia occurs.
View Article and Find Full Text PDFA persistently increased T-cell large granular lymphocyte (T-LGL) count in the blood of more than 2 × 10/L for at least 6 months is necessary for a reliable diagnosis of T-LGL leukemia. In cases with LGL counts of approximately 0.5-2 × 10/L, a diagnosis of T-LGL leukemia can be made if clonal rearrangement of T-cell receptor () genes is present and if the patient shows typical manifestations of T-LGL leukemia, such as cytopenia, splenomegaly, or concomitant autoimmune disease.
View Article and Find Full Text PDFThe non-leukemic T cell large granular lymphocytic leukemia variant with marked splenomegaly and neutropenia in the setting of rheumatoid arthritis - Felty syndrome and hepatosplenic T cell lymphoma mask.
Am J Blood Res
June 2021
T cell large granular lymphocytic (T-LGL) leukemia is a rare type of mature T cell neoplasm. The typical features of T-LGL leukemia include an increased number of large granular lymphocytes in the peripheral blood, cytopenia (most commonly neutropenia), and mild-to-moderate splenomegaly. Up to 28% of patients with T-LGL leukemia have rheumatoid arthritis (RA).
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