Characterization of KDM5 lysine demethylase family substrate preference and identification of novel substrates.

The KDM5/JARID1 sub-family are 2-oxoglutarate and Fe(II)-dependent lysine-specific histone demethylases that are characterized by their Jumonji catalytic domains. The KDM5 family is known to remove tri-/di-methyl modifications from lysine-4 of histone H3 (i.e.

PeSA 2.0: A software tool for peptide specificity analysis implementing positive and negative motifs and motif-based peptide scoring.

There are a vast number of molecular interactions that occur at the cellular level. Among these molecular interactions, interactions between multiple proteins are a widely studied area of research due to the importance of these interactions in cellular function and their potential in drug development. PeSA is a desktop application developed to facilitate the in vitro peptide study analysis to predict protein-protein interactions.

Development and reliability of the Mealtime Social Interaction Measure for Long-Term Care (MSILTC).

Mealtimes are important social events in retirement (RH) and long term care homes (LTC). This manuscript describes the development, refining and scaling of the MSILTC as well as inter-observer reliability. Two facilities provided access to their RH (n~100) and LTC (n~30-45) dining rooms.

Preventable rhabdomyolysis in prison inmates.

Two inmates of our county jail suffered painful, life-threatening illness, and our taxpayers had considerable financial loss, as the result of self-inflicted rhabdomyolysis. We found reports of three similar cases from other states. Since prisoners are treated in a variety of medical facilities, this illness may be more common than reports indicate.