Publications by authors named "N A Richardson"
Stigma surrounding mental health, particularly among men, remains a significant barrier to men engaging with support services for their mental health. Despite increasing evidence of interventions targeting different aspects of stigma reduction, there is a notable gap in the literature concerning male-specific mental health stigma reduction interventions and on the underlying behavior change techniques (BCTs) used to reduce stigma. The purpose of this review is to synthesize the evidence relating to the impact of mental health stigma reduction interventions among men and to explore the underlying BCTs associated with each intervention.
View Article and Find Full Text PDFDysregulation and loss of immune tolerance towards pancreatic β-cell autoantigens are features of type 1 diabetes (T1D). Until recently, life-long insulin injection was the only approved treatment for T1D, and this does not address the underlying disease pathology. Antigen-specific immunotherapy (ASI) seeks to restore tolerance and holds potential as a new therapeutic strategy for treating autoimmune diseases with well characterised antigens.
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- In April 2023, the FDA approved polatuzumab vedotin-piiq, combined with rituximab, cyclophosphamide, doxorubicin, and prednisone (pola+R-CHP), for adults with untreated diffuse large B-cell lymphoma or high-grade B-cell lymphoma, given a high International Prognostic Index score.
- The approval was based on the POLARIX trial, which showed a longer progression-free survival (PFS) for patients receiving pola+R-CHP compared to the standard R-CHOP regimen, with a statistically significant result.
- Despite the PFS benefit, there were concerns over the modest improvements and no significant gains in overall survival (OS), prompting further
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- The opioid overdose crisis in the USA is worsening due to law enforcement strategies targeting unregulated drug markets, which inadvertently push users towards riskier suppliers and unknown drug potency.
- A study in Indianapolis showed that neighborhoods suffering from structural racism and economic issues experienced higher rates of non-fatal overdoses, particularly after drug seizures by law enforcement.
- The research indicates that such seizures can significantly increase the likelihood of subsequent overdoses in the community, suggesting a need for decriminalization and increased support for safer drug use practices.
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- * The World Health Organization's updated guidelines in October 2023 limit primaquine use in breastfeeding women, assuming it could harm infants with G6PD deficiency, although there's ongoing anticipation for tafenoquine recommendations.
- * Recent studies argue for lifting primaquine restrictions due to findings showing very low infant exposure to the drug in breastfeeding scenarios, suggesting minimal risk to infants while highlighting the public health benefits of preventing malaria relapses in mothers.