Publications by authors named "N A Rajagopal"
Article Synopsis
- Antibody variable regions are responsible for binding to specific antigens, but they can also interact non-specifically, affecting the performance of antibody therapeutics in various ways.
- Researchers analyzed over 300,000 antibody sequences to find that the heavy chain mainly determines non-specific interactions due to its properties, such as positive charge and hydrophobicity, which can be assessed using a machine learning model.
- The study identifies key features, particularly those involving tyrosine, that influence both non-specific binding and specific antigen recognition, providing insights for antibody design and understanding molecular immunology.
Research into mosquito-borne illnesses faces hurdles because feeding fresh animal blood to rear female mosquitoes presents logistical, economic, and safety challenges. In this study, a shelf-stable additive (spray-dried porcine blood; SDPB) hypothesized to supply accessible hemoglobin was evaluated within an alternative meal (AM) containing whey powder and PBS for rearing the yellow fever mosquito . LC-MS/MS proteomics, microbial assays, and particle reduction techniques confirmed and characterized the functionality of hemoglobin in SDPB, while engorgement, fecundity, egg viability, and meal stability bioassays assessed AM performance.
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- Niemann-Pick disease type C (NPC) is a rare and serious brain disorder caused by gene mutations, with most cases linked to specific protein faults.
- This disease causes problems in how cells handle fats and calcium, which leads to damage in the brain, especially in a part called the cerebellum.
- Researchers found that a protein called Amyloid Precursor Protein (APP) affects the disease's progress, and losing APP function increases brain damage and alters important cell processes.
Hydrogen is a fuel of the future that has the potential to replace conventional fossil fuels in several applications. The quickest and most effective method of producing pure hydrogen with no carbon emissions is water electrolysis. Developing highly active electrocatalysts is crucial due to the slow kinetics of oxygen and hydrogen evolution, which limit the usage of precious metals in water splitting.
View Article and Find Full Text PDFTight junctions are cell-cell adhesion complexes that act as gatekeepers of the paracellular space. Formed by several transmembrane proteins, the claudin family performs the primary gate-keeping function. The claudin proteins form charge and size-selective diffusion barriers to maintain homeostasis across endothelial and epithelial tissue.
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