Publications by authors named "N A Plummer"
Purpose: To assess the non-inferiority of mean absolute prediction error (APE) of the Argos (Movu, a Santec company) compared with the IOL Master 700 (Carl Zeiss Meditec AG) and Lenstar LS900 (Haag-Streit AG) biometers utilizing the Barrett Universal II (BUII) formula for power calculations in short, medium, and long axial length eyes.
Methods: This was a retrospective chart review of prediction error from 3 biometers (Argos, IOLMaster 700, and Lenstar LS900). Biometer measurement order was determined using blocked randomization.
Background: Identifying women at highest or lowest risk of perinatal intensive care unit (ICU) admission may enable clinicians to risk stratify women antenatally so that enhanced care or elective admission to ICU may be considered or excluded in birthing plans. We aimed to develop a statistical model to predict the risk of maternal ICU admission.
Methods: We studied 762,918 pregnancies between 2005 and 2018.
Article Synopsis
- Researchers used genetically engineered mice and cell lines to study how the depletion of endoplasmic reticulum (ER) calcium stores activates specific calcium entry channels (SOCE) that primarily rely on Orai1 molecules.
- They discovered that Orai1 is the dominant calcium entry pathway compared to Orai2 and Orai3, and this process does not require functional TRPC molecules, as shown by experiments using cells with inactive TRPC genes.
- The study also found that even though the TRPC genes were disrupted, both store-depletion-activated calcium entry and receptor-operated calcium entry (ROCE) still relied on Orai1, leading to the establishment of a new strain of mice called TRPC heptaKO mice, which are
Locus coeruleus noradrenaline depletion and its differential impact on CO-induced panic and hyperventilation in male and female mice.
Prog Neuropsychopharmacol Biol Psychiatry
August 2024
CO exposure has been used to investigate the panicogenic response in patients with panic disorder. These patients are more sensitive to CO, and more likely to experience the "false suffocation alarm" which triggers panic attacks. Imbalances in locus coeruleus noradrenergic (LC-NA) neurotransmission are responsible for psychiatric disorders, including panic disorder.
View Article and Find Full Text PDFPurpose: Factors increasing the risk of maternal critical illness are rising in prevalence in maternity populations. Studies of general critical care populations highlight that severe illness is associated with longer-term physical and psychological morbidity. We aimed to compare short- and longer-term outcomes between women who required critical care admission during pregnancy/puerperium and those who did not.
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