Influence of occupational vibration on development of resistance to insuline and of II type diabetes mellitus.

The authors revealed influence of occupational vibration on development of resistance to insulin and of II type diabetes mellitus in miners. With that, increased serum insulin level was diagnosed in the workers. Occurrence of patients with.

[Choice of informative laboratory biomarkers for the early identification of changes in neurohumoral regulation and carbohydrate exchange in workers of the mining and mechanical engineering industry].

The diagnostic significance of hormones and integral indices of pituitary-adrenal, pituitary-thyroid and pituitary-gonadal system and carbohydrate metabolism (ACTH (corticotropin), aldosterone, cortisol, TSH (thyroid-stimulating hormone), free triiodothyronine (fT3), free thyroxine (fT4), luteinizing hormone (LH), follicle-stimulating hormone (FSH), total and free testosterone, insulin, integral pituitary-adrenal index (IPAI), the pituitary-thyroid index (PTI), indices of carbohydrate metabolism (Caro and HOMA-IR) was studied for the early diagnostics of disorders of neurohumoral regulation in workers of mining and mechanical engineering industries. The most informative indices, permitting to identify disorders of carbohydrate metabolism are established to be indices of insulin resistance (index Caro and index NOMA-IR) and the determination of insulin in serum. For the identification of changes in pituitary adrenal, pituitary-thyroid and pituitary-gonadal system in patients with vibration disease, sensory-neural hearing loss, comorbidity indexes IGNI, ITI, concentrations of LH and total testosterone are of the most diagnostically significance.

Mitochondrial energy-dissipating systems (alternative oxidase, uncoupling proteins, and external NADH dehydrogenase) are involved in development of frost-resistance of winter wheat seedlings.

Gene expression, protein synthesis, and activities of alternative oxidase (AOX), uncoupling proteins (UCP), adenine nucleotide translocator (ANT), and non-coupled NAD(P)H dehydrogenases (NDex, NDPex, and NDin) were studied in shoots of etiolated winter wheat (Triticum aestivum L.) seedlings after exposure to hardening low positive (2°C for 7 days) and freezing (-2°C for 2 days) temperatures. The cold hardening efficiently increased frost-resistance of the seedlings and decreased the generation of reactive oxygen species (ROS) during further cold shock.

[Methodological approaches to choosing informative laboratory biomarkers and their complexes for the early detection of the influence of harmful factors on man and for the diagnosis of occupational diseases].

Methodological approaches and strategy have been developed to choose informative laboratory biomarkers for the early and preclinical diagnosis and to detect the negative influence of harmful industrial and environmental factors. The paper considers whether the diagnostic value of laboratory tests can be defined, by studying the relationship of endogenous exposure (effect) and the proportion of subjects with the changed level of a biomarker (response) to the dose of a substance, stage of disease, and length of service. Due to the polysyndromic pattern of many occupational diseases, it is shown to be most expedient to carry out a few tests characterizing different aspects of the pathogenesis of disease.