[The informative laboratory biomarkers for detection of negative impact of vibration on organism of workers].

The analysis was carried out concerning new characteristics of diagnostic informativeness of particular biochemical, immunologic, cytochemical and hematologic indicators under impact of vibration on human organism. It is established that high diagnostic informativeness is typical for indicators of oxidation metabolism (alpha-superoxide dismutase, myeloperoxidase in neutrophils, alpha-tokopherol), humoral immunity (IgA, IgG), hematologic indicators (corpuscular volume, peroxide hemolysis of erythrocytes, thrombocytes aggregation velocity) and level of creatinine in urine reflecting damages of muscular tissue. The levels of biomarkers mentioned above begin to alter in healthy workers and in individuals under suspicion of vibration disease.

[Influence of vibration on changes in S100B protein content of peripheral blood in miners].

The authors studied influence of vibration on serum neurotropic protein S100B level in miners. Vibration appeared to cause significant effect on increase of this protein level. With that, there is a moderate correlation between the protein level and intensity of the vibration effect.

[Effect of vibration, noise, physical exertion and unfavorable microclimate on carbohydrate metabolism in workers engaged into mining industry and machine building].

The authors studied influence of vibration, noise, physical overexertion and microclimate on carbohydrates metabolism and insulin resistance in metal mining industry workers. Findings are that vibration disease appeared to have maximal effect on insulin resistance test results and insulin level. The authors suggested biomarkers for early diagnosis of insulin resistance disorders in metal mining industry workers.

[Biologic markers for early diagnosis of effects caused by exposure to coal dust in miners].

The authors studied changes in several laboratory values of coal miners in Russian Federation, defined information value of these changes and suggested complex of methods for early preclinical diagnosis of negative effects caused by coal dust in the miners. Dust-related respiratory diseases were proved to develop by stages on molecular level.

[The choice of laboratory biomarkers for early detection of vibration unfavorable impact on human organism].

The vibration impact on various biochemical, citochemical, immunologic and hematological indicator was studied. It is established that the indicators of oxidative metabolism (the activity of blood superoxide dismutase, neutrophil myeloperoxidase and malonic dialdehyde concentration), the level of immunoglobulin A, M and G, the activity of alkaline and acid phosphatase in neutrophils, the content of creatinine in urine are changed on the pre-clinical stage. The increase of concentration of hemoglobin begins under vibration disease 1 and the character of alteration in erythrocytes volume depends on the evidence of vibration impact.