[Specific features of toxicological profile of gemcitabine, an antitumour agent from the group of anti-metabolites].

Gemicitabine (2',2'-difluorodesoxycitidine) is a relatively new medicinal product from the group of anti-metabolites used as the first line therapy of pancreatic cancer, non-pulmonary cancer, and breast cancer. However, analysis of its toxicity spectrum revealed a large number of adverse events associated with the clinical application of this product. This fact is ascribed to the narrow range of therapeutic usages of this cytostatic preparation (from 25 mg/kg to 27 mg/kg).

Determination of the distribution of trace elements in human hair as a function of the position on the head by SRXRF AND TXRF.

On reviewing the data in the literature it is obvious that the differences in the concentrations of certain special elements in human hair for a various number of people are too large to be used as standards or deviations from standards for determining the trace-elemental composition of hair. New questions have arisen with the publication of non-compatible data. What is the distribution of elements on the donor's head area? What is the character of this distribution? Is the distribution function identical for all elements? Hair samples were taken from five points on the heads of six people.

[Clinical effectiveness and pharmacokinetic characteristics of cefotaxime in premature infants with pneumonia].

Satisfactory efficacy of cefotaxime in treatment of premature infants with pneumonia during the first month of their life was shown. Dosing of the drug was studied. It was noted that the filtration function of the kidneys in the newborn premature infants influenced the blood levels of cefotaxime and its renal excretion.