[The experimental use of surfagon, a synthetic analog of luliberin, in follicular ovarian cysts].

The use of a synthetic peptide analog of LH-RH agonist--[D-Ala6, des Gly10, Pro9]-LH-RH ethylamide (surfagon) at microdoses and in short courses returned to normal the ovulatory cycle in the anovulatory condition in rats and caused luteinization of follicular cysts in rats and cows with further normalization of ovarian function. It is assumed that surfagon will be effective for the treatment of anovulatory condition and ovarian follicular cysts in women.

[The effect of nizoral on hypophyseal gonadotropic function and the production of sex steroid hormones by the testes and ovaries in human subjects and experimental animals].

Experiments with mature male and female rats and female mice have shown that nizoral, a nonsteroid estrogenic drug, in a dose of 10 mg/kg stimulates estradiol production in male and female rats, suppresses basal and stimulates LH production, promotes a relative predominance of FSH in female animals, and suppresses FSH in male rats. In humans of a reproductive age, orally taking 200 mg of nizoral during 1-26 weeks, the drug stimulates FSH and LH production, suppressing estradiol production in men. The blood levels of prolactin, testosterone and progesterone are unchanged (the hypophyseal gonadotropic and the peripheral steroid hormones have been radioimmunoassayed).

[Biological activity of surfagon--a synthetic luliberin agonist].

The biological activity of surfagon (D-Ala6-desGly10-Pro9-ethylamide), a synthetic LH-RH agonist, is dozens of times higher than that of LH-RH in the test of rat hypophyseal stimulation of gonadotropin secretion in vivo and in vitro and in the ovulation induction test. A dose of surfagon required for the stimulation of LH secretion was considerably lower than that for the stimulation of FSH secretion. It may permit the use of surfagon in clinical practice for selective stimulation of secretion either of LH or total gonadotropins--LH and FSH.