[Experimental morphological rationale for the use of cultures of multipotent mesenchymal stem cells in combination with biomaterials in the reconstruction of the pelvic floor].

Unlabelled: To date, descension of the pelvic floor is a fairly common gynecological pathology that requires surgical treatment. The development of cellular technologies suggests that the use of multipotent mesenchymal stem cells (MMSC) in the treatment of this pathology can stimulate the regeneration of damaged tissue and contribute to the reconstruction of the structures of the pelvic floor.

Objective: to evaluate the effectiveness of using MMSC in combination with biological and synthetic materials in vitro and in vivo with descension of the pelvic floor.

Effects of T-activin and vitamin E on toxicity and antitumor activity of cyclophosphamide.

We studied the effect of combination treatment with T-activin and vitamin E on acute toxicity and antitumor activity of cyclophosphamide in mice. Combined administration of these preparations 1.37-fold increased the maximum permissible dose of cyclophosphamide without affecting its LD(50)and delayed mouse death from cyclophosphamide toxicity.

[Corrective effects of tocopherol on changes in indices of the protective activity of phagocytes under the action of the herbicide 2,4-DA].

An experimental study on non-inbred rats indicated the toxic effect of a single dose of the herbicide 2,4-dichlorophenoxyacetic acid amine salt in a dose of 240 mg/kg on phagocytic defense processes appeared as phasic changes in the concentration of peripheral leukocytes, in the microbicidal, absorptive, and oxidative activity of polymorphonuclear leukocytes and peritoneal macrophages till day 60 of the follow-up. The course administration of vitamin E produced a beneficial effect on most study indices under aftereffect of a toxicant, which was mostly manifested in the blood levels of leukocytes and in the microbicidal capacity of phagocytes.

[A combination of immunostimulants as a method for correcting secondary immunodeficiencies].

The specific features of the action of combinations of immunostimulants (levamisole, prodigiozan, methyluracil) on a primary immune response to EB, GST and resistance to experimental infection have been studied. It has been shown that levamisole eliminates stimulation by methyluracil and prodigiozan of a primary immune response, lithium carbonate is also an antagonist of prodigiozan. Vitamin E increases the stimulating effect of prodigiozan rather than oxymethacil.