Staffing Paradigm for Infection Prevention and Control in the Era of Antimicrobial Resistance: the Veterans Health Administration Experience.

Antimicrobial resistance and other emerging healthcare complexities continue to challenge infection prevention and control (IPC) resources. The Veterans Health Administration developed a comprehensive prevention approach to address multidrug-resistant organisms (MDROs), including a unique staffing model to complement infection preventionists. In particular, the MDRO Prevention Coordinator was established to support MDRO prevention initiatives.

Cytotoxicity assays for cancer drug screening: methodological insights and considerations for reliable assessment in drug discovery.

The importance of cytotoxicity assays in in vitro drug discovery investigations has led to their rising profile. Drugs and other substances can disrupt cell membranes, limit protein synthesis, and bind irreversibly to receptors, all of which lead to cell death in cancer cells. To precisely measure the cell death resulting from these damages, one must choose a cytotoxicity test that meets specific criteria.

Variation in partial direct costs of dry cow therapy on 37 large dairy herds.

The objective of this observational study was to estimate partial direct costs of dry cow antibiotic therapy (DCT) protocols used on 37 large dairy herds in Wisconsin and to estimate the potential monetary savings and reduction in antimicrobial usage (AMU) if selective DCT was used. Partial direct costs of DCT were calculated using costs of intramammary (IMM) antimicrobials and teat sealants. Data were retrospectively collected on 37 large dairy farms for a period of 1 yr and included the total number of cows dried off, types of IMM antimicrobial used, and product prices (obtained from farm invoices).

Food Insecurity Modifies the Association Between the Gut Microbiome and the Risk of Cognitive Impairment in Adults.

Background: Recent studies have shown associations between relative abundances of specific gut microbes and cognitive function; however, few studies have explored the potential interplay between the gut microbiome and food insecurity in association with the risk of cognitive impairment (RCI). This study investigated the role of food insecurity as an effect modifier between the gut microbiome, including groups of gut microbes (microbial cliques), and RCI.

Methods: Data came from the Survey of the Health of Wisconsin and its ancillary Wisconsin Microbiome Study.

Examining the implementation of a multi-site evidence-based intervention to reduce fluoroquinolone usage: A qualitative content analysis of staff interviews to identify facilitators and barriers.

Unlabelled: Clostridioides difficile infection is the most common healthcare-associated infection, causing almost half a million infections in the United States annually. Inappropriate antibiotic usage is a known risk factor. Antibiotic stewardship efforts aim to optimize prescribing.