[Postradiation structural changes in the thymocyte and lymphocyte plasma membranes in the fractional irradiation of rats].

On days 1 and 4 after fractionated irradiation of rats with dose of 0.75 Gy changes in thymocyte and lymphocyte plasma membrane structures were studied. Structural parameters of fluorescence probe auramin binding, viscosity of free lipids and lipids bound with integral proteins as well as structural changes of membrane protein structure were determined.

[Structural damages and DNA synthesis in bone marrow and peripheral blood cells in myelodepression induced by cytostatic preparations].

Some structural and functional indices of the genome state of rat myelopoietic cells after cytostatic ingestion are studied by the immunofluorescent method and by 3H-thymidine incorporation. It is shown that administration of cyclophosphamide causes structural and functional damages of hemopoietic cells. It is suggested that the intensity of repair potentials is a leading factor in restoration of depressed hemopoiesis.

[Structural-functional state of the genetic apparatus of blood leukocytes in breast cancer patients during cytostatic therapy].

Functional state of genetic apparatus was studied in leukocytes of patients with carcinoma of mammary gland at the III-IV stage by measuring incorporation of 3H-thymidine into DNA as well as by monitoring impairment of DNA structure using immunofluorescent procedure and antibodies to DNA. The studies were carried out before, in the middle period and at the end of the antitumour chemotherapy. The structure-functional state of genetic apparatus was injured in circulating leukocytes in blood of oncological patients.

[Use of DNA antibodies for detecting DNA radiation injuries in the bone marrow cell nuclei of irradiated animals].

Impairments in DNA from brain stem cell nuclei of X-ray irradiated animals were studied at early steps after irradiation using antibodies to single-stranded DNA. A possibility was shown to detect by means of an immunochemical technique the irradiation-induced impairments of DNA in brain stem cells. Detection of the impairment was possible within 3 hrs after high doses of the irradiation (206.