Modification and Use of Naturally Renewable Cardanol-Type Prepolymers in One-Component Silyl-Terminated Prepolymer Sealant Systems.

The current research is devoted to integrating naturally renewable cardanol derivatives into one-component silyl-terminated-polyether-based prepolymer systems to improve climatic resistance and obtain materials with versatile mechanical properties that could be significant to various sectors of the economy. Various cardanol-type products are used in industries that require high climatic resistance, and thus combining cardanol with commercially available silyl-terminated polyether prepolymers would improve its material climatic resistance, maintaining its market and application value as well as improving material sustainability. The results obtained in this work show that depending on how the cardanol prepolymer Ultra Lite 513 is modified, it is possible to increase the elasticity (670%) or tensile strength (104%) of the material as well as significantly increase the climatic resistance of the material, thus improving the quality and sustainability of the adhesive compared to existing silyl-terminated-prepolymer-based adhesives on the market.

PEG-Polymeric Nanocarriers Alleviate the Immunosuppressive Effects of Free 4-Thiazolidinone-Based Chemotherapeutics on T Lymphocyte Function and Cytokine Production.

Purpose: Our study aimed to assess the effects of anticancer 4-thiazolidinone-based free water-insoluble therapeutics Les-3288 and Les-3833 and their waterborne complexes with branched PEG-containing polymeric carriers (A24-PEG550 and A24-PEG750) on immune response.

Methods: Human peripheral blood was used to study in vitro lymphocyte proliferative function, leukocyte phagocytic activity and respiratory burst, and cytokine production.

Results: The binding of the polymer to the anticancer drug Les-3288, which is intended to mitigate the immunosuppressive effects of the free drug on the proliferative activity of T lymphocytes and T-dependent B cells, demonstrated comparable efficacy for both A24-PEG750 and A24-PEG550 nanocarriers.

Generation and Characterization of Three Novel Mouse Mutant Strains Susceptible to Audiogenic Seizures.

The mechanisms of epileptogenesis after brain injury, ischemic stroke, or brain tumors have been extensively studied. As a result, many effective antiseizure drugs have been developed. However, there are still many patients who are resistant to therapy.

Molecular mechanisms of corpus callosum development: a four-step journey.

The Corpus Callosum (CC) is a bundle of axons connecting the cerebral hemispheres. It is the most recent structure to have appeared during evolution of placental mammals. Its development is controlled by a very complex interplay of many molecules.