Rheography and echocardiography were used to study central and intracardiac hemodynamic parameters in 196 patients with Functional Classes I-II from the screening of the main antianginal drugs during an acute pharmacological test under bicycle ergometric monitoring. It was established that the hemodynamic type of circulation and left ventricular end-diastolic and end-systolic volumes may be used as criteria for the differential choice of antianginal agents. The values of these parameters are given for sustac, propranolol, verapamil, nifedipine and sustac plus propranolol.
View Article and Find Full Text PDFDistinct impairments in energy metabolism were detected in erythrocytes of patients with persistent stenocardia. These impairments occurred both in the rate of high-energy substances synthesis and in their utilization. Possible mechanisms for regulation of bioenergetic processes in red blood cells under conditions of ischemic heart disease are discussed.
View Article and Find Full Text PDFThe paper provides strong evidence for the fact that it is essential to take differential and individual approaches to the treatment of patients with stable angina with due regard for potentialities of their realization at various stages of cardiological care. A method of choosing antianginal agents on an individual basis was proposed, which was suitable for wide application in in- and outpatient settings. It was concluded that this method was comparable with the paired bicycle exercise method, which was based on the examination of 31 patients with Functional Classes II-III angina.
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