Novel Selective Cardiac Myosin-Targeted Inhibitors Alleviate Myocardial Ischaemia-Reperfusion Injury.

Purpose: Reperfusion of the ischaemic heart is essential to limit myocardial infarction. However, reperfusion can cause cardiomyocyte hypercontracture. Recently, cardiac myosin-targeted inhibitors (CMIs), such as Mavacamten (MYK-461) and Aficamten (CK-274), have been developed to treat patients with cardiac hypercontractility.

Exploring nasopharyngeal carcinoma genetics: Bioinformatics insights into pathways and gene associations.

Introduction: The pathogenesis of nasopharyngeal carcinoma (NPC) is intricate, influenced by a combination of factors including host genetics, viral infection and environmental elements, resulting in genetic and epigenetic modifications. Despite a positive prognosis for early-stage patients, most NPC cases are diagnosed at an advanced stage, highlighting the pressing need for enhanced accessibility to early diagnosis and treatment. The underlying molecular pathways driving NPC progression remain elusive.

Marrow talaromycosis as the initial presentation in a case of Burkitt lymphoma.

Talaromyces marneffei is a thermally dimorphic fungus which causes opportunistic infections in immunocompromised individuals. The diagnosis of T. marneffei infection rests on the microscopic demonstration of the fungus in the tissues and/or isolation of the fungus from clinical specimens.

Ilizarov External Fixator Versus Orthofix LRS in Management of Femoral Osteomyelitis: A Propensity Score Matched Analysis.

Purpose: Treatment of osteomyelitis (OM) is challenging. Ilizarov bone transport is a commonly used technique for management of OM. The recently introduced limb reconstruction system (LRS) has been effectively used for management of OM.