Publications by authors named "N A Lone"
Purpose: Benzodiazepines and z-drugs are often prescribed to critical care survivors due to high prevalence of mental health problems and insomnia. However, their safety has not been studied in this population.
Methods: Retrospective cohort study of 28,678 adult critical care survivors hospitalised in 2010 and 2018: 4844 prescribed benzodiazepines or z-drugs, matched to 23,834 unexposed survivors using UK Clinical Practice Research Datalink linked datasets.
Importance: For hospitalized critically ill adults with suspected sepsis, procalcitonin (PCT) and C-reactive protein (CRP) monitoring protocols can guide the duration of antibiotic therapy, but the evidence of the effect and safety of these protocols remains uncertain.
Objective: To determine whether decisions based on assessment of CRP or PCT safely results in a reduction in the duration of antibiotic therapy.
Design, Setting, And Participants: A multicenter, intervention-concealed randomized clinical trial, involving 2760 adults (≥18 years), in 41 UK National Health Service (NHS) intensive care units, requiring critical care within 24 hours of initiating intravenous antibiotics for suspected sepsis and likely to continue antibiotics for at least 72 hours.
Article Synopsis
- The study investigates how living alone or with someone who is chronically ill affects outcomes for hip fracture patients aged 50 and older.
- It found that 56% of 12,089 patients lived alone, who were generally older and had more long-term health conditions compared to those living with a co-resident.
- Living alone and living with someone with dementia significantly increased the risk of needing care home admission after a hip fracture, but living alone had no substantial effect on the likelihood of emergency hospital admission within 30 days.
Article Synopsis
- Survivors of critical illness often develop mental health issues and sleep disorders, leading to the study of new benzodiazepine and z-drug prescriptions among these individuals.
- A retrospective study analyzed data from over 52,000 adult survivors who didn't use these medications before hospitalization, finding that 5.2% received a new prescription within 90 days post-discharge and 2.5% had persistent use.
- Key factors associated with new prescriptions included a history of insomnia, anxiety, depression, and recent opioid use, while sex didn't impact prescribing rates and older patients were less likely to be prescribed these medications.
Background: People hospitalised for coronavirus disease 2019 (COVID-19) have elevated incidence of diabetes. However, it is unclear whether this is due to shared risk factors, confounding or stress hyperglycaemia in response to acute illness.
Methods: We analysed a multicentre prospective cohort study (PHOSP-COVID) of people ≥18 years discharged from NHS hospitals across the United Kingdom following COVID-19.