Efficient parameter generation for constrained models using MCMC.

Mathematical models of complex systems rely on parameter values to produce a desired behavior. As mathematical and computational models increase in complexity, it becomes correspondingly difficult to find parameter values that satisfy system constraints. We propose a Markov Chain Monte Carlo (MCMC) approach for the problem of constrained model parameter generation by designing a Markov chain that efficiently explores a model's parameter space.

Scalable Gromov-Wasserstein Based Comparison of Biological Time Series.

A time series is an extremely abundant data type arising in many areas of scientific research, including the biological sciences. Any method that compares time series data relies on a pairwise distance between trajectories, and the choice of distance measure determines the accuracy and speed of the time series comparison. This paper introduces an optimal transport type distance for comparing time series trajectories that are allowed to lie in spaces of different dimensions and/or with differing numbers of points possibly unequally spaced along each trajectory.

Dynein localization and pronuclear movement in the C. elegans zygote.

Centrosomes serve as a site for microtubule nucleation and these microtubules will grow and interact with the motor protein dynein at the cortex. The position of the centrosomes determines where the mitotic spindle will develop across all cell types. Centrosome positioning is achieved through dynein and microtubule-mediated force generation.

TRANSFORMATION OF THE LEARNING PROCESS IN HIGHER EDUCATION INSTITUTIONS UNDER THE INFLUENCE OF THE PANDEMIC COVID-19.

Objective: The aim: To analyze the challenges and approaches used in medical universities in different countries during the transfer of training from offline to online format during the COVID-19 pandemic.

Patients And Methods: Materials and methods: Electronic databases of Scielo, Scopus and PubMed were searched using keyword searches.

Conclusion: Conclusions: The use of a large number of online tools and ICTs to develop the clinical skills of medical students has become a real pedagogical breakthrough in medical education.

Sustainability of agricultural and wild cereals to aerotechnogenic exposure.

In recent decades, the problem of the constantly increasin level of anthropogenic load on the environment is becoming more and more acute. Some of the most dangerous pollutants entering the environment from industrial emissions are heavy metals. These pollutants are not susceptible to biodegradation over time, which leads to their accumulation in the environment in dangerous concentrations.