Publications by authors named "N A Kovalev"
Unlabelled: Single diastereomers of 4-hetaryl-2-pyrrolidone-3(5)-carbo- and 2-[4-hetaryl-2-pyrrolidon-1-yl]acetohydrazides were used in reactions with 2,4-pentanedione, providing (3,4)-3-, (4,5)-5-(3,5-dimethyl-1-pyrazole-1-carbonyl)- and 1-[2-(3,5-dimethyl-1-pyrazol-1-yl)-2-oxoethyl]-4-hetaryl-2-pyrrolidones. The structures of the synthesized compounds were confirmed by spectral methods and X-ray structural analysis. Some of the obtained compounds were shown to possess nootropic and anxiolytic activity.
View Article and Find Full Text PDFA series of new pyrimidine thioethers, recognized as the key intermediates in the synthesis of S-DABO antivirals, were prepared and evaluated both in vivo and in silico. The purpose of this evaluation was to find novel structural analogues of the known antihypoxic drug Isothiobarbamine endowed with improved pharmacological profile. The in vivo studies led to the identification of compounds 5c, 5e, and 5f endowed with antidepressant/anxiolytic, performance enhancing, and nootropic properties.
View Article and Find Full Text PDFThe influence of the nature of amine solutions on the frequency spectrum of the electrochemical impedance of the bipolar membrane aMB-2m is investigated. Moreover, the effect of the circulation rate of solutions in the electrodialyzer chambers on the volt-ampere characteristics of the Ralex AMH and MA-40L anion-exchange membranes and the aMB-2m bipolar membrane has been investigated. The diffusion characteristics of various types of anion-exchange membranes in a system containing dimethylammonium sulfate ((DEA)HSO), as well as the diffusion characteristics of the Ralex AMH membrane in systems with methylammonium sulfate, dimethylammonium sulfate, diethylammonium sulfate, and ethylenediammonium sulfate ((MA)HSO, (DMA)HSO, (DEA)HSO, EDAHSO) have been studied.
View Article and Find Full Text PDFArticle Synopsis
- Replication of positive-strand RNA viruses relies on cellular membranes and host proteins, specifically highlighting the role of Cdc48 in tomato bushy stunt virus (TBSV) replication.
- The study shows that TBSV infection increases Cdc48 expression in plants and that Cdc48 interacts with TBSV replication proteins, which is essential for the virus's replicase assembly and function.
- Interestingly, excess Cdc48 can disrupt the viral replicase-RNA complex and facilitate the recruitment of other host proteins, suggesting Cdc48's potential role as a common factor for various RNA viruses across different species.
[Antioxidant effect of cortexin, cerebrolysin and actovegin in rats with chronic cerebrovascular insufficiency].
Zh Nevrol Psikhiatr Im S S Korsakova
September 2021
Objective: To compare the antioxidant effects of cortexin, cerebrolysin and actovegin in rats with chronic brain ischemia.
Material And Methods: Chronic brain ischemia was modeled in male rats by 50% stenosis of the common carotid arteries. Forty days after surgery, the animals received 2 ten-day courses of therapy, separated by a break of 10 days.