Genome organization regulates nuclear pore complex formation and promotes differentiation during oogenesis.

Genome organization can regulate gene expression and promote cell fate transitions. The differentiation of germline stem cells (GSCs) to oocytes in involves changes in genome organization mediated by heterochromatin and the nuclear pore complex (NPC). Heterochromatin represses germ cell genes during differentiation, and NPCs anchor these silenced genes to the nuclear periphery, maintaining silencing to allow for oocyte development.

A nuclear architecture screen in identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fate.

The association of genomic loci to the nuclear periphery is proposed to facilitate cell type-specific gene repression and influence cell fate decisions. However, the interplay between gene position and expression remains incompletely understood, in part because the proteins that position genomic loci at the nuclear periphery remain unidentified. Here, we used an Oligopaint-based HiDRO screen targeting ∼1000 genes to discover novel regulators of nuclear architecture in cells.

Efficient uptake of Sr and Co using fabricated inorganic sorbent for reducing radiation doses of simulated low-level waste.

The present study investigated the sorption behavior of Sr and Co radionuclides from aqueous solutions onto tin molybdate (SnMo) sorbent. SnMo has been synthesized using the precipitation method and was characterized using four analytical techniques including FT-IR, XRD, SEM, and XRF. The sorption studies applied on Sr and Co include the effect of shaking time, pH, concentration, and saturation capacity.

Assessment of the Role of Urinary Heparanase in Lupus Nephritis Patients and Its Correlation with Disease Activity.

Assessing the activity of lupus nephritis (LN) with novel biomarkers is a promising noninvasive diagnostic tool for managing systemic lupus erythematosus (SLE). We assessed the ability of urinary heparanase to identify LN and its relation to the disease's activity. This crosssectional study had 90 subjects: 70 patients with SLE and 20 healthy controls.