Publications by authors named "N A Korsun"
Background: Mixed infections can worsen disease symptoms. This study investigated the impact of mixed infections with viral and bacterial pathogens in patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: Using the in-house multiplex PCR method, we tested 337 SARS-CoV-2 positive samples for co-infections with three bacterial and 14 other viral pathogens.
After two seasons of absence and low circulation, influenza activity increased significantly in the winter of 2022-2023. This study aims to characterize virological and epidemiological aspects of influenza infection in Bulgaria during the 2022-2023 season and perform a phylogenetic/molecular analysis of the hemagglutinin () and neuraminidase () sequences of representative influenza strains. Influenza A and B viruses generate new genetic groups/clades each season, replacing previously circulating variants.
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- * Seasonal respiratory viruses were detected using multiplex PCR and next-generation sequencing, highlighting the highest coinfection rate (15%) in patients 16 years and younger.
- * Whole-genome sequencing revealed various genetic groups among the detected viruses and multiple amino acid substitutions, emphasizing the need for understanding viral interactions for effective treatment and prevention strategies.
Article Synopsis
- Respiratory syncytial virus (RSV) is a significant cause of respiratory infections, and a study in Bulgaria aimed to assess its prevalence and genetic diversity alongside other viruses from 2020 to 2023.
- Out of 3,047 patients with respiratory issues, 59.5% tested positive for viral pathogens, with RSV being the second most common at 10.9%, especially affecting children under 5 years old.
- The research found a marked increase in RSV cases in the 2022-2023 season, with specific genetic strains identified, indicating a resurgence post-COVID-19 restrictions.
Introduction: Endemic human coronaviruses (eHCoVs) are found worldwide and usually result in mild to moderate upper respiratory tract infections. They can lead to more severe illnesses such as croup, bronchiolitis, and pneumonia in vulnerable populations. During the coronavirus disease 2019 (COVID-19) pandemic, information on HCoV prevalence and incidence and clinical impact of co-infections of HCoV with SARS-CoV-2 was lacking.
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