Anti-EGFR anchored paclitaxel loaded PLGA nanoparticles for the treatment of triple negative breast cancer. In-vitro and in-vivo anticancer activities.

The aim of the present study is to analyze the viability of anti-EGFR anchored immunonanoparticle (INP) bearing Paclitaxel (PTX) to specifically bind the EGFR protein on the TNBC cells. The NP was prepared by nanoprecipitation and characterized the particle size, charge, entrapment of drug and release of it. The anti-EGFR anchored and the integrity was confirmed by SDS-PAGE.

Uptake of Radium-223 Dichloride and Early [F]NaF PET Response Are Driven by Baseline [F]NaF Parameters: a Pilot Study in Castration-Resistant Prostate Cancer Patients.

Purpose: The purpose of this study is to identify predictive factors on baseline [F]NaF positron emission tomography (PET)/computed tomography (CT) of early response to radium-223 dichloride after 3 cycles of treatment in metastatic castration-resistant prostate cancer patients.

Procedures: Analysis of 152 metastases was performed in six consecutive patients who underwent [F]NaF PET/CT at baseline and for early monitoring after 3 cycles of radium-223 dichloride. All metastases depicted on whole-body [F]NaF PET/CT were contoured and CT (density in Hounsfield units, sclerotic, mixed, or lytic appearance) as well as [F]NaF [maximum standardized uptake value (SUV), SUV, and lesion volume (V)] patterns were recorded.

Influence of metabolic stress on the inheritance of cell determination in the moss, Pottia intermedia.

Epigenetically-determined apogamy in aposporous regenerants of the moss Pottia intermedia persists during vegetative propagation, the capacity of apogamy being inherited by individual aposporous protonemal cells. To test Bauer-Lazarenko's proposal that stable apogamy in mosses may be due to some self-replicating cytoplasmic factor, the effects of different metabolic stress treatments on the expression of apogamy have been tested. Chronic metabolic stress caused by long-term growth of autotrophic aposporous protonema on mineral medium with 0.

High temperature alters the growth reaction of Pottia protonemata.

Under gravistimulation, dark-grown protonemata of Pottia intermedia revealed negative gravitropism with a growth rate of approximately 28 micrometers hour-1 at room temperature (20 degrees C). In 7 days, the protonema formed a bundle of vertically oriented filaments. At an elevated temperature (30 degrees C), bundles of vertically growing filaments were also formed.

Influence of gravity on the photomorphism of secondary moss protonemata.

In dark-grown plantlets of the moss, Pottia intermedia, negatively gravitropic secondary protonemata differentiate from the superficial cells of leafy shoots. When transferred to the light, distal parts of the protonemata nearest to the apical cells begin to ramify and the apical cells of the side branches as well as of the main protonemal filaments often differentiate as buds. Dark-grown protonemata were oriented horizontally and illuminated from below with white light of different intensities.