Short-term administration of hydrocortisone into rats (within 7 days) stimulated 1.25(OH)2D3 synthesis in kidney and led to accumulation of the metabolite in blood serum, small intestinal mucose and bones. After long-term administration of hydrocortisone within 28 days synthesis of 1.
View Article and Find Full Text PDFPhysiological dose of 1,25(OH)2D3 (0.03 microgram) normalized the phosphorus-calcium metabolism and improved the state of bone tissue in rats treated with hydrocortisone. An increased dose of 1,25(OH)2D3 (0.
View Article and Find Full Text PDFHigh content of phosphorus in the diet (1.8% of phosphorus in the diet, Ca:P ratio 1:3) accelerated the development of hypocalcemia and osteoporosis and increased their degree in rats which received hydrocortisone (3.5 mg/10 g bw a day for 4 weeks).
View Article and Find Full Text PDFThe increase of phosphorus content up to 1.2-1.8% in the diet (the calcium/phosphorus ratio 1:2 or 1:3) accelerates the development and raises the rate of hypocalcemia and osteoporosis in rats administered pharmacological doses of hydrocortisone (3.
View Article and Find Full Text PDF