Use of antiviral therapy in patients with chronic hepatitis C.

Introduction: The presence of background HCV infection cannot be overestimated in view of the prevalence of chronic hepatitis C and the risk of adverse outcomes of this disease. Purpose of this study was to evaluate the effectiveness of the combined use of antiviral therapy (Roferon + Vero-Ribavirin) and resort factors in patients with chronic hepatitis C in the phase of replication.

Material And Methods: We observed 48 patients with chronic hepatitis C; the minimum level of activity of the process defined the phase of replication.

[Endovascular closure of iatrogenic arteriovenous anastomosis of the iliac artery and vein].

The presented herein clinical case report concerns successful endovascular closure of a iatrogenic lesion of the iliac artery and inferior vena cava with formation of a pathological arteriovenous anastomosis manifesting itself by venous thromboembolic syndrome and severe right-ventricular insufficiency.

[Laboratory and clinical study of nitazole].

Nitazole, a drug from the nitrotiazole group, was shown to be active in vitro against bacteroides, peptococci, peptostreptococci, clostridia, staphylococci, colibacilli and streptococci. By its activity and antibacterial spectrum nitazole had some advantages over metronidazole, a drug from the nitroimidazole group. Experimental study of nitazole aerosole formulation in 4 models of purulent wounds of rabbits infected by Bacteroides fragilis, B.

[Nitazole--an antimicrobial substance].

The antibacterial activity of protistocide drug nitazole has been revealed for the first time in the 80's at the Laboratory of Clinical Microbiology of the Mechnikov Research Institute of Microbiology and Immunology. Unlike other imidazoles, such as metronidazole and tinidazole, nitazole acts as the inhibitor of growth of gram-positive facultative and obligate anaerobic microorganisms as well as gram-negatives except for Pseudomonas aeruginosa and Proteus. Nitazole, as a main antimicrobial agent of many multicomponent drugs which are created on the hydrophilic basis (matrices), is particularly useful for topical treatment of wounds and burns in the first and second phases of these processes.