Faculty of Prehospital Care, Royal College of Surgeons Edinburgh guidance for medical provision for wilderness medicine.

To support leaders and those involved in providing medical care on expeditions in wilderness environments, the Faculty of Pre-Hospital Care (FPHC) of The Royal College of Surgeons of Edinburgh convened an expert panel of leading healthcare professionals and expedition providers. The aims of this panel were to: (1) provide guidance to ensure the best possible medical care for patients within the geographical, logistical and human factor constraints of an expedition environment. (2) Give aspiring and established expedition medics a 'benchmark' of skills they should meet.

Nursing and finance: making the connection.

Nursing and finance are critical to each other's success in maintaining financial viability and providing high-quality care. Finance departments should educate, inform, communicate, and empathize. Nursing departments should think creatively, get involved in budget committees and board meetings, and set an example of collaboration and cooperation.

Selected predictors of registered nurses' intent to stay.

This paper reports initial findings from a longitudinal study of autonomy, willingness to risk, exit/voice (E/V) and managerial environment (ME) as predictors of registered nurses' intent to stay (ITS) that is being conducted at eight Midwestern hospitals in the USA. In this two-stage study, initial findings are based on responses from 524 staff nurses. Due to the nature of the ITS variable, two logistic regression analyses were computed to test the predictive relationships of the independent variables.

In vivo antitumor activity of a panel of four monoclonal antibody-vinca alkaloid immunoconjugates which bind to three distinct epitopes of carcinoembryonic antigen.

A panel of four murine monoclonal antibodies apparently directed against three distinct epitopes of carcinoembryonic antigen (CEA) was conjugated via oxidized carbohydrate groups to 4-desacetylvinblastine-3-carboxyhydrazide. The resulting antibody-vinca conjugates were evaluated for antitumor activity against 2-9-day-established LS174T human colorectal carcinoma xenografts. The antibodies (immunoglobulin G, IgG) employed in this study were 11.

In vivo antitumor activity of a monoclonal antibody-Vinca alkaloid immunoconjugate directed against a solid tumor membrane antigen characterized by heterogeneous expression and noninternalization of antibody-antigen complexes.

It is widely believed that antigen heterogeneity and noninternalization of antigen-antibody complexes will severely limit the antitumor activity of monoclonal antibody-drug conjugates. The B72.3 monoclonal antibody binds to a tumor-associated antigen which is heterogeneously expressed in human carcinomas (J.