Publications by authors named "N A Healy"
Breast cancer is the most prevalent cancer in women in Europe, and while all European countries have some form of screening for breast cancer, disparities in organization and implementation exist. Breast density is a well-established risk factor for breast cancer; however, most countries in Europe do not have recommendations in place for notification of breast density or additional supplementary imaging for women with dense breasts. Various supplemental screening modalities have been investigated in Europe, and when comparing modalities, MRI has been shown to be superior in cancer detection rate and in detecting small invasive disease that may impact long-term survival, as demonstrated in the Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial in the Netherlands.
View Article and Find Full Text PDFThe top 100 most-cited articles on artificial intelligence in breast radiology: a bibliometric analysis.
Insights Imaging
December 2024
Introduction: Artificial intelligence (AI) in radiology is a rapidly evolving field. In breast imaging, AI has already been applied in a real-world setting and multiple studies have been conducted in the area. The aim of this analysis is to identify the most influential publications on the topic of artificial intelligence in breast imaging.
View Article and Find Full Text PDFArticle Synopsis
- Breast cancer is very rare in pediatric patients, and while ultrasound (US) is often used for those showing symptoms, this study questions its necessity.
- The research examined 579 patients under 19, mainly girls, and found that most had normal clinical exams and US results, with only a small percentage requiring biopsies or surgeries.
- Findings suggest that if clinical evaluations are normal, breast US can be skipped entirely, which would have saved 52% of the patients from unnecessary ultrasound procedures.
Article Synopsis
- The study reviews the effectiveness of preoperative Computed Tomographic Angiography (CTA) in mapping Thoraco-dorsal Artery Perforator (TDAP) flaps used in breast and soft tissue reconstruction, noting that traditional methods can yield false results.
- Five studies were analyzed, highlighting a high risk of bias, with a total of 72 patients and varying degrees of agreement between CTA findings and standard Doppler techniques.
- The research indicates a lack of standardized scanning protocols, calls for further investigation to clearly establish the role of CTA in TDAP planning, and suggests that better imaging may aid in surgical preparation despite current challenges.
Objective: To evaluate the overall survival (OS) of patients with chronic lymphocytic leukemia (CLL) receiving either ibrutinib monotherapy as a first-line (1L) treatment or chemotherapy/chemoimmunotherapy-based (CT/CIT) regimens in 1L followed by ibrutinib in the second line (1L CT/CIT-2L ibrutinib) after disease progression by emulating a randomized trial comparing both treatment sequences.
Methods: Patient-level data from the RESONATE-2 trial (NCT01722487) and real-world PHEDRA databases were analyzed. Three scenarios were considered using the following data sources: (1) RESONATE-2, (2) combined RESONATE-2/PHEDRA, (3) combined RESONATE-2/PHEDRA for 1L ibrutinib and PHEDRA for 1L CT/CIT-2L ibrutinib.