Publications by authors named "N A Franken"
Normal tissue reactions vary significantly among patients receiving the same radiation treatment regimen, reflecting the multifactorial etiology of late radiation toxicity. Predicting late radiation toxicity is crucial, as it aids in the initial decision-making process regarding the treatment modalities. For patients undergoing radiotherapy, anticipating late toxicity allows for planning adjustments to optimize individualized care.
View Article and Find Full Text PDFEfficacy of current treatment options for cervical cancer require improvement. Previous studies have shown the enhancing effects of the addition of PARP1-inhibitors to chemoradiotherapy and thermoradiotherapy. The aim of our present study was to test efficacy of different combinations of treatment modalities radiotherapy, cisplatin, hyperthermia and PARP1-inhibitors using tumor models, treated patient samples and tumor models.
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- The study aimed to validate the predictive ability of the γ-H2AX foci decay ratio (γ-FDR) for late radiation toxicity in a diverse group of pelvic cancer patients, following earlier findings in prostate cancer patients.
- Analysis involved 88 patients with long-term follow-up, assessing toxicity through both physician and patient-reported measures, while examining γ-FDR values in irradiated lymphocytes.
- Results showed lower toxicity rates compared to prior studies, with no significant correlation between γ-FDR levels and severe toxicity, indicating a minimal decline in patients' quality of life post-treatment.
Radiosensitization by Hyperthermia Critically Depends on the Time Interval.
Int J Radiat Oncol Biol Phys
March 2024
Purpose: Hyperthermia is a potent sensitizer of radiation therapy that improves both tumor control and survival in women with locally advanced cervical cancer (LACC). The optimal sequence and interval between hyperthermia and radiation therapy are still under debate.
Methods And Materials: We investigated the interval and sequence in vitro in cervical cancer cell lines, patient-derived organoids, and SiHa cervical cancer hind leg xenografts in athymic nude mice and compared the results with retrospective results from 58 women with LACC treated with thermoradiotherapy.
Introduction: Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) aims to treat microscopic disease left after CytoReductive Surgery (CRS). Thermal enhancement depends on the temperatures achieved. Since the location of microscopic disease is unknown, a homogeneous treatment is required to completely eradicate the disease while limiting side effects.
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