Publications by authors named "N A Farber"
Introduction: Electroconvulsive therapy (ECT) is a highly effective treatment for refractory depression, but it may also cause cognitive side effects. Despite decades of use, the mechanisms by which ECT exerts both its antidepressant and cognitive effects are still poorly understood, with the latter substantially limiting referral and adherence to therapy. ECT induces changes in correlated neural activity-functional connectivity-across various brain networks, which may underlie both its clinical efficacy and associated cognitive side effects.
View Article and Find Full Text PDFBackground: Apomorphine is a dopaminergic candidate therapy to improve recovery in patients with prolonged disorders of consciousness (PDoC). Behavioural improvements were previously described in non-controlled case series, but its efficacy and neural mechanisms remain largely unknown. This open-label controlled study using multimodal outcome measures investigates the action of apomorphine in severely brain-injured patients.
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- This study aimed to analyze and compare the types of bacteria found in ear infections (otorrhea) in children with and without cleft palate who had tympanostomy tubes inserted.
- The researchers reviewed data from children under 18 who underwent the procedure between 2017 and 2021, highlighting that 38.9% experienced significant ear drainage requiring further medical attention.
- They discovered higher rates of otorrhea in children with cleft palate (50%) versus those without (35.7%), with certain bacteria being notably resistant to antibiotics, particularly fluoroquinolones, though differences in resistance patterns were not significant between the two groups.
Introduction: Late-life treatment-resistant depression (LL-TRD) is common and increases risk for accelerated ageing and cognitive decline. Impaired sleep is common in LL-TRD and is a risk factor for cognitive decline. Slow wave sleep (SWS) has been implicated in key processes including synaptic plasticity and memory.
View Article and Find Full Text PDFFor the process of transient transfection (TTF), DNA is often transported into the cells using polyplexes. The polyplex uptake and the subsequent transient expression of the gene of interest are of great importance for a successful transfection. In this study, we investigated a 3D-printed microfluidic system designed to facilitate direct TTF for suspension of CHO-K1 cells.
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