[Kainate receptors in the hippocampus of rat strains with different levels of the nervous system excitability].

Glutamate receptors in the central nervous system play a significant role in the mechanisms of differential adaptation to the environmental conditions. However, structural and functional parameters of kainate receptors (KR) under normal conditions and during exposure to stress are not well characterized. Therefore, the aim of this research was to 1) study the distribution and the quantity of KR GluR 5/6/7 subunits; 2) examine their changes in the pyramidal cell layer of the hippocampus in rat strains with have genetically determined distinctions in the levels of nervous system excitability following the exposure to short-term emotional-painful stress; 3) estimate the sensitivity of hippocampal pyramidal neurons to the action of KR agonist -kainic acid.

[Systemic control of the molecular, cell, and epigenetic mechanisms of long-lasting consequences of stress].

Based on M.E. Lobashev's views of the systemic control of genetic and cytogeneitc processes and a substantial effect of excitability on plastic changes in the central nervous system (CNS), the effect of prolonged emotional and pain stress (PEPS) on the molecular, cell, and epigenetic mechanisms of injury memory was studied in rat strains bred for a certain excitability of the nervous system.

[Heterochromatin characteristics in hippocampal neurons of rats with different excitability of the nervous system under conditions of posttraumatic stress disorder modeling].

Two lines of rats, selected according to the excitability of nervous system to the action of an electric current, served as the model objects to study the changes of heterochromatin characteristics in neurons of hippocampus (area CA3) 24 hours, 2 weeks, 2 and 6 months after exposure to prolonged emotional painful stress. It was shown that exposure to stress caused changes in the area, occupied by heterochromatin, only in rats with low-excitability: it was decreased 24 hours, 2 weeks and 2 months following the stress, while it was increased after 6 months as compared to control values. Thus, it was demonstrated for the first time that long-term modifications of heterochromatin structural characteristics of neurons in hippocampus (area CA3) could depend on genetically determined functional state of the nervous system.

[Architecture of the X chromosome, expression of LIM kinase 1, and recombination in the agnostic mutants of Drosophila: a model of human Williams syndrome].

As the Human Genome and Drosophila Genome Projects were completed, it became clear that functions of human disease-associated genes may be elucidated by studying the phenotypic expression of mutations affecting their structural or functional homologs in Drosophila. Genomic diseases were identified as a new class of human disorders. Their cause is recombination, which takes place at gene-flanking duplicons to generate chromosome aberrations such as deletions, duplications, inversions, and translocations.

[Characteristics of heterochromatin of heterophase nuclei from interphase neurons of various brain structures selected for the nervous system excitability].

Quantitative characteristics (the area and number of chromocenters) of the interphase C-heterochromatin in the nuclei of pyramidal neurons of the midbrain reticular formation, sensorimotor cortex, and hippocampus (CA3) of rat strains with different genetically determined excitability were studied in the normal state of the animals and after exposure to a short-term emotional pain stress. The results indicate a relationship between the excitability of the nervous system and structural-functional state of the neuronal interphase heterochromatin. The role of cytogenetic features of different brain structures in the CNS functioning and behavior and their relation with genetically determined excitability of the nervous system are discussed.