Publications by authors named "N A Bryan"
Article Synopsis
- Vancomycin-resistant Enterococcus faecium (VRE) poses major healthcare challenges, especially for vulnerable patients like hospitalized individuals and astronauts.
- A study tested 42 E. faecium samples in simulated microgravity and found varied antibiotic resistance, with some strains showing increased biofilm production and desiccation tolerance.
- These findings highlight the adaptability of VRE in space-like conditions, emphasizing the importance of understanding its behavior to ensure crew health during long-term space missions.
Article Synopsis
- Aquatic ecosystems like Lake Wilcox harbor diverse bacterial strains, many of which can potentially harm humans, highlighting a significant health risk.
- Among 11 bacterial isolates studied, 67% were identified as potential human pathogens, indicating considerable genetic diversity and a reservoir for multiple pathogenic strains.
- The research uncovered widespread antibiotic resistance, particularly to β-lactams and tetracycline, emphasizing the importance of monitoring pathogens in such ecosystems to understand their genetic evolution and ecological impact.
Article Synopsis
- Targeting PI3K/AKT/PTEN signalling offers promising therapy options for B-cell malignancies, particularly diffuse large B-cell lymphoma (DLBCL), despite challenges with existing PI3K inhibitors due to toxicity.
- The AKT inhibitor capivasertib, when used with the BCL-2 inhibitor venetoclax, shows significant therapeutic benefits in preclinical DLBCL models, inducing tumor cell death effectively.
- Adding rituximab to this drug combination enhances treatment outcomes, suggesting a potentially effective strategy for managing DLBCL patients who are resistant to standard therapies.
Evaluation of pediatric patients for intestinal transplantation in the modern era.
J Pediatr Gastroenterol Nutr
August 2024
Objectives: To review recent evaluations of pediatric patients with intestinal failure (IF) for intestinal transplantation (ITx), waiting list decisions, and outcomes of patients listed and not listed for ITx at our center.
Methods: Retrospective chart review of 97 patients evaluated for ITx from January 2014 to December 2021 including data from referring institutions and protocol laboratory testing, body imaging, endoscopy, and liver biopsy in selected cases. Survival analysis used Kaplan-Meier estimates and Cox proportional hazards regression.
The physical basis of phase separation is thought to consist of the same types of bonds that specify conventional macromolecular interactions yet is unsatisfyingly often referred to as 'fuzzy'. Gaining clarity on the biogenesis of membraneless cellular compartments is one of the most demanding challenges in biology. Here, we focus on the chromosome passenger complex (CPC), that forms a chromatin body that regulates chromosome segregation in mitosis.
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