HapCNV: A Comprehensive Framework for CNV Detection in Low-input DNA Sequencing Data.

Copy number variants (CNVs) are prevalent in both diploid and haploid genomes, with the latter containing a single copy of each gene. Studying CNVs in genomes from single or few cells is significantly advancing our knowledge in human disorders and disease susceptibility. Low-input including low-cell and single-cell sequencing data for haploid and diploid organisms generally displays shallow and highly non-uniform read counts resulting from the whole genome amplification steps that introduce amplification biases.

Atraumatic Fracture of Newer Generation Ceramic Head Three Days Post-op: A Case Report.

A 73-year-old female experienced an atraumatic fracture of a BIOLOX delta ceramic femoral head following uncomplicated right total hip arthroplasty using a ceramic-on-polyethylene bearing. The fracture occurred post-operatively, as revealed by radiography after the patient reported a clunking sensation and leg shortening. Revision surgery involved replacing the fractured head and liner with careful removal of ceramic debris.

Minimum twenty-year follow-up of fixed-vs mobile-bearing total knee arthroplasty: Double blinded randomized trial.

Introduction: Mobile-bearing (MB) inserts, designed to minimize aseptic loosening and to reduce contact stresses leading to polyethylene wear, are an alternative to fixed-bearing (FB) inserts. Most studies have shown no significant difference between MB and FB constructs, and there is limited long-term data comparing the two constructs [1,2,3,4]. The purpose of this study was to report the outcomes of a randomized controlled trial comparing MB versus FB inserts on patients with minimum 20-year follow-up.

Movi: A fast and cache-efficient full-text pangenome index.

Pangenome indexes are promising tools for many applications, including classification of nanopore sequencing reads. Move structure is a compressed-index data structure based on the Burrows-Wheeler Transform (BWT). It offers simultaneous O(1)-time queries and O(r) space, where r is the number of BWT runs (consecutive sequence of identical characters).

Postnatal foot length measurement as a proxy to identify low birth weight for frontline health workers in rural Sindh Province, Pakistan: a diagnostic accuracy study.

Objective: To assess the diagnostic accuracy of postnatal foot length (FL) measurements as a proxy to identify low birth weight (LBW) for frontline healthcare workers in rural Sindh Province, Pakistan.

Design: A community-based cross-sectional study.

Setting: This study was conducted in the catchment area of Global Network's Maternal and Newborn Health Registry, Thatta, Sindh Province, Pakistan, from January to June 2023.