Publications by authors named "N A Boughattas"
Unlabelled: Introduction-Aim: The iatrogenic risk in the elderly is a real public health problem due to its frequency and seriousness. Our study aimed to analyze the epidemiological, clinical and chronological aspects of adverse drug reactions occurring in elderly subjects and to identify the incriminated drugs.
Methods: We carried out a retrospective study of all the observations of adverse drug reactions in elderly subjects, notified to the Clinical Pharmacology department of Monastir over a period of 17 years (2004 - 2020).
Article Synopsis
- Thiopurine drugs are used to treat conditions like inflammatory bowel disease, and their metabolism is influenced by the enzymes TPMT and ITPA.
- This study focuses on Tunisian patients to assess how genetic factors and other variables affect the pharmacokinetics of thiopurine drugs.
- The research found specific genetic variants and identified gender as a significant factor affecting drug variability, emphasizing the importance of TPMT testing for optimal treatment safety and efficacy.
Article Synopsis
- * Using a nonparametric approach, the model examined how factors like age and kidney function (creatinine clearance) affected drug distribution and clearance.
- * Results showed that the model accurately predicts vancomycin levels, highlighting the need for personalized dosing to ensure optimal effectiveness and safety for patients with varying degrees of renal impairment.
Background: A prospective validation of pharmacokinetic population (Pk pop) of Tacrolimus (Tac) for dose adjustment in kidney transplant patients was assessed in only one study. The present study was aimed at prospectively evaluating the performance of our previously developed Tac- Pk pop model in predicting trough concentration (C0) in Tunisian kidney transplant patients.
Patients And Method: It was a prospective study including patients who had undergone kidney transplantation at Monastir-Nephrology Department.
Soil erosion is a serious and complex environmental problem worldwide, especially in the centre west of Tunisia. Whereas the construction of hill reservoirs is part of the soil and water conservation strategy, many of these have a siltation problem. Dhkekira is one of the smallest watersheds in central Tunisia whose most lithological formation consists of materials that are quite susceptible to water erosion.
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