[Specificity of a panel of monoclonal antibodies to group A Streptococcus polysaccharide and search for cross reactions with mammalian tissues].

A panel of monoclonal antibodies (McAb) to different determinants of group A Streptococcus polysaccharide (A-PS) has been studied. As revealed in this study, A-PS contains at least 4 determinants, common with different epidermal antigens. McAb, cross-reacting (CR) with different mammalian tissue antigens, have not been found to be group-specific.

[The characteristics of the immune response to the polysaccharide determinants of Streptococcus group A in rheumatism].

As shown in this study, the formation of antibodies, at least, to the determinants (DT) of polysaccharide of group A streptococcus (A-PS), common with epidermal antigens, occurs in rheumatic fever. Two DT include N-acetylglucosamine; DT common with epidermal basal cell antigen (DT-1) and DT common with antigen of the perinuclear zone of the cytoplasm of cells of differentiated layers (DT-2). Two other DT seem to contain only rhamnose; DT common with the cytoplasm of cells of differentiated layers (DT-3) and DT common with epidermal antigen, characteristic of the cytoplasm of cells of all epidermal layers (DT-4).

[Comparison of the frequency of detection of autoantibodies to epidermal antigens with the level of antibodies to polysaccharide of group A Streptococcus and the number of T-suppressors in glomerulonephritis].

By the acute glomerulonephritis (GN) of streptococcal etiology, autoantibodies (AA) reacting with the basal layer of skin epithelium (BLSE) are discovered. The presence of this AA's correlate with the high level of antibodies to the streptococcal group A polysaccharide (A-PS). In the control sera such AA's and the high level antibodies to A-PS are discovered very rarely.