The influence of gender on the clinical and dynamic indicators of alcohol dependence, the level of aggression of patients taking into account comorbidity with affective disorders.

To assess the influence of comorbid affective disorders (AD) on the clinical and dynamic indicators of alcohol dependence syndrome (ADS), the level of aggression in patients, and to examine gender differences. Two groups were analyzed: Group F10 ( = 149) included patients with ADS without comorbid AD, and group F10 + F3 ( = 61) of patients with ADS comorbid with AD. Clinical-psychopathological, clinical-follow-up, psychometric, and statistical methods were used.

[Indicators of the background spectral power of the EEG in patients with alcohol dependence complicated by exogenous organic brain disease].

Objective: To conduct a comparative analysis of EEG spectral power indicators in patients with alcoholism with- or without exogenous organic brain disease.

Material And Methods: An analysis of 119 EEG of patients with alcohol dependence was carried out. The presence of exogenous organic brain disease in patients was assessed retrospectively (through anamnesis).

Association of Peripheral Markers of Oxidative Stress with Clinical Parameters and Inflammatory Factors in Alcoholic Patients.

One of the fundamental problems in studying addiction is elucidation of mechanisms of alcohol dependence (AD) development. Disturbances of cellular redox balance and inflammation play an important role in AD pathogenesis. Deciphering associations between biological and clinical indicators can elucidate molecular mechanisms of disease pathogenesis.

Alcohol-Induced Activation of Chemokine System and Neuroinflammation Development.

Chemokines are immunoregulatory proteins with pleiotropic functions involved in neuromodulation, neurogenesis, and neurotransmission. The way chemokines affect the CNS plays an important role in modulating various conditions that could have negative impact on CNS functions, including development of alcohol use disorders. In this review, we analyzed the literature data available on the problem of chemokine participation in pathogenesis, clinical presentation, and remission of alcohol use disorders both in animal models and in the study of patients with alcoholism.