Publications by authors named "N A Bianchi"
Article Synopsis
- The hypothalamus-pituitary testis axis and growth hormone (GH) pathways are interconnected, but GH's impact on male sexual function and fertility remains debated due to mixed research findings.
- GH excess contributes to male sexual health issues, notably causing erectile dysfunction in about 40.2% of cases and impairing fertility by reducing sperm quality, including concentration and motility.
- GH deficiency may also lead to erectile dysfunction, though its effects on fertility are not well established; overall, GH disorders adversely affect male sexual and general health, with insufficient research on testosterone replacement therapy benefits.
Background: Archaea and Bacteria are distinct domains of life that are adapted to a variety of ecological niches. Several genome-based methods have been developed for their accurate classification, yet many aspects of the specific genomic features that determine these differences are not fully understood. In this study, we used publicly available whole-genome sequences from bacteria ( ) and archaea ( ).
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- The Letter reports the most accurate measurement so far of the matter-antimatter imbalance during Pb-Pb collisions at a high energy level of 5.02 TeV.
- It utilizes the Statistical Hadronization framework to determine precise values for the electric charge and baryon chemical potentials, μ_{Q} and μ_{B}.
- The analysis of antiparticle-to-particle yield ratios shows that the collisions create a system that is generally baryon-free and electrically neutral at midrapidity.
It has been shown that vertical transmission of the SARS-CoV-2 strain is relatively rare, and there is still limited information on the specific impact of maternal SARS-CoV-2 infection on vertical transmission. The current study focuses on a transcriptomics analysis aimed at examining differences in gene expression between placentas from mother-newborn pairs affected by COVID-19 and those from unaffected controls. Additionally, it investigates the in situ expression of molecules involved in placental inflammation.
View Article and Find Full Text PDFThe identification of genes involved in replicative stress is key to understanding cancer evolution and to identify therapeutic targets. Here, we show that CDK12 prevents transcription-replication conflicts (TRCs) and the activation of cytotoxic replicative stress upon deregulation of the MYC oncogene. CDK12 was recruited at damaged genes by PARP-dependent DDR-signaling and elongation-competent RNAPII, to repress transcription.
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