[Effect of monoiodoacetate and ouabain on cholinergic vasodilation in cat skeletal muscles].

The effects of a glycolysis blocking agent monoiodoacetate and of the sodium pump blocker ouabain, on cholinergic vasodilatation in skeletal muscle were studied. In acute experiments on cats, i. v.

Increase in osmolality of venous blood from skeletal muscle during cholinergic vasodilatation.

The arterio-venous difference in the osmolality of blood plasma of cat m. triceps surae was studied during sympathetic cholinergic nerve excitation. The vasodilatation was induced by stimulation of hypothalamus or the sympathetic chain, the latter after alpha-adrenoceptor blockade.

[Changes in plasma composition resulting in an increase in the osmotic pressure of venous blood during the cholinergic dilatation effect].

Stimulation of the sympathetic chain in the presence of alpha-receptor blocking agents caused cholinergic vasodilatation of the cat hind-limb vessels. The arterial-venous difference with respect to osmotic pressure (Posm), as well as to the content of K+, Na+, Ca2+, lactate, total protein, and inorganic phosphate was determined in blood samples collected during vasodilatation. Sympathetic stimulation in the presence of alpha-receptor-blocking agents agents increased the conductance of the hind-limb vessels and Posm of the venous blood (7.

[Cholinergic sympathetic influences on blood flow and cyclic nucleotide concentration in skeletal muscles].

The content of 3.5 cGMP increased twofold and the content of 3.5 cAMP remained unchanged in the cat skeletal muscle during vasodilatation evoked by hypothlalamic stimulation.