Publications by authors named "N A Beckmann"
Background: Emergency/trauma radiology artificial intelligence (AI) is maturing along all stages of technology readiness, with research and development (R&D) ranging from data curation and algorithm development to post-market monitoring and retraining.
Purpose: To develop an expert consensus document on best research practices and methodological priorities for emergency/trauma radiology AI.
Methods: A Delphi consensus exercise was conducted by the ASER AI/ML expert panel between 2022-2024.
Osteoarthritis can be treated with hyaluronic acid derivatives, such as Durolane manufactured by Bioventus (Hill, 2017), particularly when conventional treatments prove ineffective. In osteoarthritic joints, the synovial fluid has a lower concentration of hyaluronic acid compared to healthy joints. Intra-articular therapy with exogenous hyaluronic acid can improve viscoelastic properties, enhance chondrocyte synthesis, reduce cartilage degradation, and alleviate pain associated with osteoarthritis (Migliore and Procopio in Clin Cases Miner Bone Metab.
View Article and Find Full Text PDFCell-cell contact formation of polarized epithelial cells is a multi-step process that involves the co-ordinated activities of Rho family small GTPases. Consistent with the central role of Rho GTPases, a number of Rho guanine nucleotide exchange factors (GEFs) and Rho GTPase-activating proteins (GAPs) have been identified at cell-cell junctions at various stages of junction maturation. As opposed to RhoGEFs and RhoGAPs, the role of Rho GDP dissociation inhibitors (GDIs) during cell-cell contact formation is poorly understood.
View Article and Find Full Text PDFArticle Synopsis
- - Dual specificity protein phosphatase 6 (DUSP6) is important in regulating late-onset Alzheimer's disease (AD), with lower DUSP6 levels linked to worse dementia ratings in humans and decreased levels observed in a mouse model of the disease.
- - Researchers injected AAV5-DUSP6 into the brains of 5xFAD mice to increase DUSP6 expression and found that it improved memory deficits and reduced amyloid plaques in male mice but not in female mice, while also decreasing microglial activation in both sexes.
- - Although DUSP6 overexpression helped reduce neuroinflammation and activated microglia in both male and female mice, the improvement in memory was sex-dependent, indicating different underlying mechanisms