Pharmacokinetically guided dose escalation of carboplatin in epithelial ovarian cancer: effect on drug-plasma AUC and peripheral blood drug-DNA adduct levels.

Background: Platinum based drugs are active agents in epithelial ovarian cancer and increased platinum drug dose intensity is thought to lead to improved survival, because of the largely untested assumption that increased dose intensity results in an increased interaction of the platinum drug with its target, DNA. In a previously reported phase I trial (Lind et al., J Clin Oncol 1996; 14: 800-5), carboplatin dose intensity was increased by the use of G-CSF to support the bone marrow and using pharmacokinetically-guided carboplatin dosing.

A review of the processes by which ultrasound is generated through the interaction of ionizing radiation and irradiated materials: some possible applications.

The production of acoustic waves following the absorption of energy deposited by ionizing radiation, with a consequent production of localized thermal spikes has been confirmed by a number of papers published in the physics literature. This paper reviews the basic theory and presents most of the supporting experimental data. Some of the experimental methods used and the results obtained are summarized.

Digital tomosynthesis: phantom and patient studies with a prototype unit.

A prototype digital linear tomographic system has been developed and used in patient and phantom studies. Phantom work demonstrated 0.6 line pairs/mm of spatial resolution, a slice thickness of 5 mm to 6 mm, range of reconstruction of 1 cm to 20 cm above tabletop, reconstruction time of 2 to 45 seconds per slice depending on matrix size, and a 280 mm field of view at the tabletop.

Patient exposure requirements for high contrast resolution in digital radiographic systems.

The contrast resolution of modern digital radiographic equipment is primarily limited by quantum mottle. The derivation of the contrast resolution of a system as a function of radiation exposure is presented. Calculations based on this derivation show that achieving 0.