[THE INFLUENCE OF MEXIDOL AND 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE HEMISUCCINATE ON LIPOFUSCINE CONTENT IN RAT BRAIN UNDER LOCAL PERMANENT ISCHEMIA CONDITIONS].

Experiments on rats showed that 6- and 12-day course treatment by mexidol or 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate (at doses 200 mg/kg, i.p.) prevented the lipofuscin level increase in rat brain tissue, caused by occlusion of the left middle cerebral artery, both in the damaged and intact (right) cerebral hemispheres.

[STUDYING NEUROPROTECTIVE ACTIVITY OF GABA CONJUGATE WITH ARACHIDONIC ACID UNDER CONDITIONS OF LOCAL PERMANENT BRAIN ISCHEMIA IN RATS].

We have studied the effect of a GABA conjugate with arachidonic acid (AA) on the morphological state of rat brain tissues after left median cerebral artery occlusion. The results showed that a 6- and 12-day course administration of the GABA - AA conjugate at dose of 2 mg/kg (i.p.