[The effect of hypokinesia on depression and on the central GABA-A receptor complexes in the rat brain].

The influence of a 15-day hypokinesia on the development of anxiety-depression state and quantitative changes in the central GABA-A macromolecular receptor complexes in the rat brain has been investigated under conditions of the despair (forced swim) test. Simultaneously, the effects of well-known nootropic drugs picamilon and piracetam on the dynamics of state parameters in the experimental animals have been evaluated. It was found that hypokinesia led to the development of anxiety and depression accompanied by reduction in the amount of active GABA-A receptors.

[Argiopinin-binding proteins from the membrane of the bull cerebral cortex].

The 40 kDa argiopinin-binding glycoprotein has been isolated from the solubilised preparations of bovine cerebrum membranes by means of two-step biospecific chromatography on affinity sorbents with immobilized glutamate and argiopinins. This receptor component displays a specific L-[3H]glutamate binding with Kd = 0.18 +/- +/- 0.

[Histoenzymological characteristics of the adrenal cortical reaction in variants of experimental pancreatitis].

In the early stages of experiments there was a structural-metabolic reconstruction in the adrenal cortex, manifest by changes in interzonal relations and dissociation of the activity of enzymes responsible for energy supply and synthesis of steroid hormones. Analogous changes were also seen later on. However, in the early stages that process was a response to the pancreas injury, whereas in the later period it preceded the emergence of repeated lesions in the gland.

[Role of the supraoptic nucleus in the estrus regulation in rats in local hypothermia].

An extraordinary role of hypothalamic supraoptical nuclei in the ovulation process and luteinizing hormone formation was found out. Morphological studies of the rat ovaries with the affected supraoptical nuclei have shown a sharp inhibition of their function, manifesting in the decreased follicular number of sizes, atresia of primordial follicles, the inhibition of the ovarian ovulatory capacity and luteinizing hormone formation. The ovarian function remained inhibited, despite increased neurosecretory activity of the paraventricular nucleus cells in rats with the affected hypothalamic supraoptic nuclei during hypothermia.