Publications by authors named "N A Alexandrova"

One of the major problems observed in veterinary practice is articular cartilage injuries in animals. In terms of agriculture, it leads to their culling from the herd, even if they are highly productive animals. With companion animals, owners usually have to decide between euthanasia or long-term sometimes lifelong treatment of the injury by a veterinarian.

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Background: Tendon injuries are one of the most common causes of orthopedic disorders in horses. Such injuries involve a long course of treatment and recovery. The most promising method of treating these injuries is the use of recombinant proteins and gene therapy.

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Article Synopsis
  • The study investigates the genetic variations in Bacille Calmette-Guérin (BCG) vaccine strains, specifically focusing on seed lots used in Russia and their descendants linked to BCG-related diseases in children.
  • Through whole-genome sequencing, researchers compared seed lots 361, 367, and 368 with nine progeny isolates and identified specific genetic mutations that could influence vaccine efficacy and virulence.
  • The findings suggest that while genetic variations exist, they did not compromise the stability or effectiveness of the BCG vaccine, indicating that changes accumulate during the vaccine's time in the human body.
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Due to the prevalence of biofilm infections caused by Klebsiella pneumoniae, in laboratory diagnostic practice it has a great importance to obtain a standard model of Klebsiella biofilm for evaluating the bactericidal effect and effectiveness of antimicrobial drugs. Describes the method of Klebsiella biofilms formation in vitro. The intensity of biofilm formation was evaluated by the ability of bacteria to bind the crystal violet.

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When studying the effect of the metabolic products of clinical isolates of enterococci on the viability of Candida albicans, it was found that metabolites of all tested strains of Enterococcus faecium, E. faecalis had a fungistatic effect. At the same time a reliable fungicidal effect is a strain-specific feature.

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