Synthesis of photo-responsive κ-carrageenan-based hydrogels for drug delivery application.

Natural polymer-based hydrogels may act as versatile platforms in controlled drug delivery. In this regard, photoactive κ-carrageenan (κ-Crg) hydrogels modified with cinnamate (CN) groups are developed for pH-sensitive release of drugs. κ-Crg-CN derivatives containing 17 %, 33 %, and 49 % cinnamate contents, named κ-Crg-CN1, κ-Crg-CN2, and κ-Crg-CN3, respectively, are prepared and cross-linked by UV-induced [2π + 2π] cycloaddition.

Towards standardization of person-reported outcomes (PROs) in pediatric diabetes research: A consensus report.

Background: Diabetes ranks among the most common chronic conditions in childhood and adolescence. It is unique among chronic conditions, in that clinical outcomes are intimately tied to how the child or adolescent living with diabetes and their parents or carers react to and implement good clinical practice guidance. It is widely recognized that the individual's perspective about the impact of trying to manage the disease together with the burden of self-management should be addressed to achieve optimal health outcomes.

Alogliptin attenuates STZ-induced diabetic nephropathy in rats through the modulation of autophagy, apoptosis, and inflammation pathways: Targeting NF-κB and AMPK/mTOR pathway.

Aim: Diabetic nephropathy (DN) is a type of microvascular complication that arises from diabetes mellitus and leads to further health issues. Most importantly, the prevalence of DN is steadily rising in developed countries. This research explored the therapeutic benefits of alogliptin, a dipeptidyl peptidase IV (DPP-4) inhibitor, on streptozotocin (STZ)-induced DN and its underlying mechanisms in rats.

Counting on AR: EEG responses to incongruent information with real-world context.

Augmented Reality (AR) technologies enhance the real world by integrating contextual digital information about physical entities. However, inconsistencies between physical reality and digital augmentations, which may arise from errors in the visualized information or the user's mental context, can considerably impact user experience. This work characterizes the brain dynamics associated with processing incongruent information within an AR environment.