Combination of circulating miR-145-5p/miR-191-5p as biomarker for breast cancer detection.

Background: Breast cancer (BC) is the most common cancer among women worldwide. At present, there is a need to search for new, accurate, reliable, minimally invasive and cheap biomarkers in addition to existing methods for the diagnosis and prognosis of BC. The main goal of this study was to test the diagnostic value of six circulating miRNAs in Kazakh women.

Absence of mutations in the human interferon alpha-2b gene in workers chronically exposed to ionising radiation.

Individuals chronically exposed to low-level ionising radiation (IR) run the risk of harmful and long-term adverse health effects, including gene mutations and cancer development. The search for reliable biomarkers of IR exposure in human population is still of great interest, as they may have a great implementation potential for the surveillance of occupationally exposed individuals. In this context, and considering previous literature, this study aimed to identify mutations in the human interferon alpha-2b (hIFNα-2b) as a potential biomarker of occupational chronic low-dose IR exposure linking low-IR exposure to the effects on haematopoiesis and reduced immunity.

Molecular snapshot of Mycobacterium tuberculosis population in Kazakhstan: a country-wide study.

Republic of Kazakhstan is among the 27 high multidrug-resistant tuberculosis (MDR-TB) burden countries in the world. Here, we analyzed the population structure and phylogeography of Mycobacterium tuberculosis in Kazakhstan and impact of the identified genotypes on spread of drug resistant strains. A total of 159 M.

[Insertion-deletion polymorphism of mitochondrial DNA region V in Kazakh populations from different regions of Kazakhstan].

Insertion-deletion polymorphism of the mitochondrial DNA (mtDNA) region V was examined in three Kazakh populations inhabiting different regions of Kazakhstan. The 9-bp deletion was revealed in all three populations examined. In Altai population the 4-bp insertion was also found.