Management of anemia with quotidian hemodialysis.

Background: Most patients with end-stage renal disease have chronic anemia caused by inadequate erythropoietin (EPO) synthesis and require therapy with exogenous EPO to maintain recommended hematocrit and hemoglobin levels.

Methods: The London Daily/Nocturnal Hemodialysis Study compared anemia control among patients on either short daily, long nocturnal, or conventional thrice-weekly hemodialysis (HD) therapy. Patients were administered iron, either orally (900 mg/d) or intravenously (50 to 125 mg every 1 to 4 weeks), to maintain serum ferritin levels at greater than 45 ng/mL (100 microg/L) or transferrin saturations greater than 20%.