Lack of superoxide dismutase in a rad51 mutant exacerbates genomic instability and oxidative stress-mediated cytotoxicity in Saccharomyces cerevisiae.

A genetic analysis of synthetic lethal interactions in yeast revealed that the mutation of SOD1, encoding an antioxidant enzyme that scavenges superoxide anion radical, impaired the growth of a set of mutants defective in homologous recombination (HR) pathway. Hence, SOD1 inhibition has been proposed as a promising approach for the selective killing of HR-deficient cancer cells. However, we show that the deletion of RAD51 and SOD1 is not synthetic lethal but displays considerably slow growth and synergistic sensitivity to both reactive oxygen species (ROS)- and DNA double-strand break (DSB)-generating drugs in the budding yeast Saccharomyces cerevisiae.

Plasmonic color filters fabricated via oxide-based nanotransfer printing.

Plasmonic filters have recently become a topic of significant interest because they are suitable for a wide range of applications. However, effective fabrication of plasmonic filters remains a challenge. In this paper, we demonstrate a simple method for fabricating plasmonic color filters based on nanotransfer printing (nTP) , using SiO as a hard mask for Al etching.

Covalent bonding-assisted nanotransfer lithography for the fabrication of plasmonic nano-optical elements.

Many high-resolution patterning techniques have been developed to realize nano- and microscale applications of electric devices, sensors, and transistors. However, conventional patterning methods based on photo or e-beam lithography are not employed to fabricate optical elements of high aspect ratio and a sub-100 nm scale due to the limit of resolution, high costs and low throughput. In this study, covalent bonding-assisted nanotransfer lithography (CBNL) was proposed to fabricate various structures of high resolution and high aspect ratio at low cost by a robust and fast chemical reaction.

Yap1 and Skn7 genetically interact with Rad51 in response to oxidative stress and DNA double-strand break in Saccharomyces cerevisiae.

Reactive oxygen species (ROS)-mediated DNA adducts as well as DNA strand breaks are highly mutagenic leading to genomic instability and tumorigenesis. DNA damage repair pathways and oxidative stress response signaling have been proposed to be highly associated, but the underlying interaction remains unknown. In this study, we employed mutant strains lacking Rad51, the homolog of E.

Prevalence of and factors associated with osteoporosis among Korean cancer survivors: a cross-sectional analysis of the Fourth and Fifth Korea National Health and Nutrition Examination Surveys.

Background: Identifying and managing osteoporosis among cancer survivors is an important issue, yet little is known about the bone health of cancer survivors in Korea. This study was designed to measure the prevalence of osteoporosis and to assess related factors among Korean cancer survivors.

Materials And Methods: This study was designed as a cross-sectional analysis.

Alleviation of heat strain by cooling different body areas during red pepper harvest work at WBGT 33 degrees C.

The purpose of the present study was to examine the effects of different types of personal cooling equipments (PCE) on the alleviation of heat strain during red pepper harvest simulated in a climatic chamber. The experiment consisted of eight conditions: 1) Control, 2) Neck cooling scarf A with a cooling area of 68 cm2, 3) Neck cooling scarf B (cooling area 154 cm2), 4) Brimmed hat with a frozen gel pack, 5) Cooling vest (cooling area 606 cm2), 6) Hat+Neck Scarf B, 7) Hat+Vest, and 8) Hat+Neck Scarf B+Vest. Twelve subjects worked a red pepper harvest simulated in a climatic chamber of WBGT 33 degrees C.

Does wearing thermal underwear in mild cold affect skin temperatures and perceived thermal sensation in the hands and feet of the elderly?

The present study was to investigate whether increasing thermal insulation affects thermal sensation in the hands and feet; and whether aging is an influential factor in the relationship between thermal responses and subjective thermal perceptions. Six young males (YM), 5 young females (YF), 6 elderly males (OM), and 6 elderly females (OF) volunteered as subjects. Subjects conducted two trials at a constant air temperature of 19 degrees C: One condition included thermal underwear (19CUW) while the other did not (19C).