Publications by authors named "Mysarah Zahran"
In the classical model of the basal ganglia, direct pathway striatal projection neurons (dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to regulate motor function. Recent studies have re-established that dSPNs also possess axon collaterals within the globus pallidus (GPe) (bridging collaterals), yet the significance of these collaterals for behavior is unknown. Here we use in vivo optical and chemogenetic tools combined with deep learning approaches in mice to dissect the roles of dSPN GPe collaterals in motor function.
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- The classical model of the basal ganglia involves direct pathway striatal projection neurons (dSPNs) regulating motor function by projecting to specific regions, but recent findings reveal they also have collaterals in the globus pallidus externus (GPe).
- Using advanced techniques like in vivo optical and chemogenetic tools, researchers investigated the role of these collaterals in motor function, discovering that they transmit motor-related information to the GPe.
- Inhibiting the activity of dSPN GPe terminals negatively affects motor activity by influencing Npas1 neurons, suggesting that these collaterals work together with traditional pathways to enhance motor control by modulating feedback signals.