Publications by authors named "Myroslava Mytsyk"
Article Synopsis
- Researchers are studying how special cells from fat (SVF cells) can help heal damaged hearts by promoting blood vessel growth.
- They found that when these cells were grown in low oxygen conditions (hypoxia), they produced more helpful chemicals and grew better in tests with rats.
- This means that even if the blood supply is slow at first when using these cells in heart repairs, it won't stop them from helping to create new blood vessels.
Cell-based therapies show promising results in cardiac function recovery mostly through paracrine-mediated processes (as angiogenesis) in chronic ischemia. In this study, we aim to develop a 2D (two-dimensional) in vitro cardiac hypoxia model mimicking severe cardiac ischemia to specifically investigate the prosurvival paracrine effects of adipose tissue-derived stromal vascular fraction (SVF) cell secretome released upon three-dimensional (3D) culture. For the 2D-cardiac hypoxia model, neonatal rat cardiomyocytes (CM) were cultured for 5 days at < 1% (approaching anoxia) oxygen (O ) tension.
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