Publications by authors named "Myron A Gebhardt"
A sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for the quantitation of oxymorphone (OM) in human whole blood and liver. Sample preparation was done by solid-phase extraction, using deuterated OM as the internal standard. Separation was achieved using a Waters Aquity UPLC HSS T3 column.
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- - Cocaine is widely abused but is also used as a local anesthetic in medical procedures, particularly in surgeries related to the eye, ear, nose, and throat.
- - A 54-year-old man's death involved cocaine detected in his urine, but it was found to be from a medical procedure he had undergone, not from abuse.
- - A thorough investigation and review of medical records are essential to differentiate between illicit drug use and legitimate medical use to determine the accurate cause and manner of death.
Vitreous humor may serve as a useful alternative specimen for oxycodone analysis in death investigations where blood samples are not available or are of poor quality or limited quantity. The purpose of this study was to investigate the relationship between immunoassay results and gas chromatography-mass spectrometry (GC-MS) quantitation of oxycodone in postmortem vitreous humor and blood. When used with vitreous humor calibrators, the Microgenics DRI Oxycodone (EMIT) Assay was found to be linear from 25 to 500 ng/mL with an limit of detection of 25 ng/mL.
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