Publications by authors named "Myriam Spisto"
Background And Purpose: Preclinical studies of amyotrophic lateral sclerosis (ALS) have shown altered endocannabinoid (eCB) signalling that may contribute to the disease. Results from human studies are sparse and inconclusive. The aim of this study was to determine the association between serum levels of eCBs or their congeners, the so-called endocannabinoidome, and disease status and activity in ALS patients.
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- - This paper introduces VOC-ALS, a new database of voice recordings from 153 participants, including 102 ALS patients and 51 healthy controls, aimed at studying voice signals affected by ALS.
- - The recordings were made using a smartphone app during various speech tasks, such as vowel phonation and syllable repetition, allowing researchers to gather significant data on voice characteristics.
- - Metrics like harmonics-to-noise ratio and frequency variations were analyzed, showing potential for these measures to effectively identify ALS patients and assess the severity of their speech difficulties.
Article Synopsis
- The study aimed to estimate the prevalence and incidence of dementia and Alzheimer's disease (AD) in the Campania region of South Italy, using healthcare data from 2015 to 2020.
- Researchers analyzed data from individuals aged 65 and older and found that 80,392 had dementia, with a prevalence rate of 77.64 per 1,000 for any dementia and 34.05 per 1,000 for AD.
- The incidence rates were 82.10 cases of dementia and 59.89 cases of AD per 100,000 people annually, and the performance of their algorithms for detecting dementia was validated against clinical tests with good sensitivity and specificity.
Background: In amyotrophic lateral sclerosis (ALS), gait abnormalities contribute to poor mobility and represent a relevant risk for falls. To date, gait studies in ALS patients have focused on the motor dimension of the disease, underestimating the cognitive aspects.
Methods: Using a wearable gait analysis device, we compared gait patterns in ambulatory ALS patients with mild cognitive impairment (ALS MCI+; n = 18), and without MCI (ALS MCI-; n = 24), and healthy subjects (HS; n = 16) under two conditions: (1) normal gait (single task) and (2) walking while counting backward (dual task).
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with progressive loss of upper and lower motor neurons. Non-motor-symptoms, such as cognitive, emotional, autonomic, and somatosensory alterations, have been also described. Interoception represents the link between the body and brain, since it refers to the ability to consciously perceive the physical condition of the inner body, including one's heartbeat (i.
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