Assisted reproductive techniques in patients with Klinefelter syndrome: a critical review.

Objective: To summarize the existing experience with the use and success rate of assisted reproductive techniques (ART), in particular testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI), in Klinefelter patients.

Design: A systematic review of the literature, including all published case reports to date.

Patient(s): Thirty-nine reported successful pregnancies fathered by nonmosaic Klinefelter patients.